Professor Chris Hutchison
Emeritus Professor
Campus
- Publications
N-acetyl cysteine alleviates oxidative stress and protects mice from dilated cardiomyopathy caused by mutations in nuclear A-type lamins gene
- Journals
- DOI reference: 10.1093/hmg/ddy243
Xenopus LAP2β protein knockdown affects location of lamin B and nucleoporins and has effect on assembly of cell nucleus and cell viability
- Journals
- DOI reference: 10.1007/s00709-015-0861-y
Delayed self-regulation and timedependent chemical drive leads to novel states in epigenetic landscapes
- Journals
- DOI reference: 10.1098/rsif.2014.0706
The role of lamin A in cytoskeleton organization in colorectal cancer cells: A proteomic investigation
- Journals
- DOI reference: 10.4161/nucl.2.5.17775
Lamins as cancer biomarkers
- Journals
- DOI reference: 10.1042/BST0380297
B-type lamins and their elusive roles in metazoan cell proliferation and senescence
- Journals
- DOI reference: 10.1038/emboj.2012.39
Prelamin A processing and functional effects in restrictive dermopathy
- Journals
- DOI reference: 10.4161/cc.9.23.14210
A novel role for the nuclear membrane protein emerin in association of the centrosome to the outer nuclear membrane
- Journals
- DOI reference: 10.1083/jcb.200702026
Adult stem cell maintenance and tissue regeneration in the ageing context: The role for A-type lamins as intrinsic modulators of ageing in adult stem cells and their niches
- Journals
- DOI reference: 10.1111/j.1469-7580.2008.00928.x
A-type lamins are essential for TGF-β1 induced PP2A to dephosphorylate transcription factors
- Journals
- DOI reference: 10.1093/hmg/ddi316
A-type lamins: Guardians of the soma?
- Journals
- DOI reference: 10.1038/ncb1104-1062
Analysis of UV-induced damage and repair in young and senescent human dermal fibroblasts using the comet assay
- Journals
- DOI reference: 10.1016/j.mad.2004.12.002
Colonic and colorectal cancer stem cells: Progress in the search for putative biomarkers
- Journals
- DOI reference: 10.1111/j.1469-7580.2008.00917.x
Dynamic complexes of A-type lamins and emerin influence adipogenic capacity of the cell via nucleocytoplasmic distribution of β-catenin
- Journals
- DOI reference: 10.1242/jcs.026179
Expression of individual lamins in basal cell carcinomas of the skin
- Journals
- DOI reference: 10.1054/bjoc.2000.1632
Filaments made from A- and B-type lamins differ in structure and organization
- Journals
- DOI reference: 10.1242/jcs.022020
Genomic instability in laminopathy-based premature aging
- Journals
- DOI reference: 10.1038/nm1266
Increased solubility of lamins and redistribution of lamin C in X-linked Emery-Dreifuss muscular dystrophy fibroblasts
- Journals
- DOI reference: 10.1016/S1047-8477(02)00573-7
Lamin A/C binding protein LAP2α Is required for nuclear anchorage of retinoblastoma protein
- Journals
- DOI reference: 10.1091/mbc.E02-07-0450
Lamin A/C is a risk biomarker in colorectal cancer
- Journals
- DOI reference: 10.1371/journal.pone.0002988
Lamin A/C-dependent localization of Nesprin-2, a giant scaffolder at the nuclear envelope
- Journals
- DOI reference: 10.1091/mbc.E04-11-1009
Lamin A: A putative colonic epithelial stem cell biomarker which identifies colorectal tumours with a more aggressive phenotype
- Journals
- DOI reference: 10.1042/BST0361350
Lamin expression in normal human skin, actinic keratosis, squamous cell carcinoma and basal cell carcinoma
- Journals
- DOI reference: 10.1046/j.1365-2133.2003.05026.x
Lamina-associated polypeptide 2α regulates cell cycle progression and differentiation via the retinoblastoma-E2F pathway
- Journals
- DOI reference: 10.1083/jcb.200511149
Laminopathies
- Journals
- DOI reference: 10.1002/path.1655
Lamins in disease: Why do ubiquitously expressed nuclear envelope proteins give rise to tissue-specific disease phenotypes?
Lamins: building blocks or regulators of gene expression?
- Journals
- DOI reference: 10.1038/nrm950
Luminescent nonacoordinate cationic lanthanide complexes as potential cellular imaging and reactive probes
- Journals
- DOI reference: 10.1039/b301385p
NEP-A and NEP-B both contribute to nuclear pore formation in Xenopus eggs and oocytes
- Journals
- DOI reference: 10.1242/jcs.019968
Do lamins influence disease progression in cancer?
- Journals
- DOI reference: 10.1007/978-1-4899-8032-8_27
Nuclear lamins: Laminopathies and their role in premature ageing
- Journals
- DOI reference: 10.1152/physrev.00047.2005
Nucleoplasmic LAP2α-lamin A complexes are required to maintain a proliferative state in human fibroblasts
- Journals
- DOI reference: 10.1083/jcb.200606139
Partial cleavage of A-type lamins concurs with their total disintegration from the nuclear lamina during apoptosis
- Journals
- DOI reference: 10.1078/0171-9335-00282
Problems with LAP nomenclature
- Journals
- DOI reference: 10.1038/35070147
Remodelling of the nuclear lamina and nucleoskeleton is required for skeletal muscle differentiation in vitro
- Journals
- DOI reference: 10.1242/jcs.01630
Spectraplakins and nesprins, giant spectrin repeat proteins participating in the organization of the cytoskeleton and the nuclear envelope.
The inner nuclear membrane protein Emerin regulates β-catenin activity by restricting its accumulation in the nucleus
- Journals
- DOI reference: 10.1038/sj.emboj.7601230
The lethal phenotype of a homozygous nonsense mutation in the lamin A/C gene
- Journals
- DOI reference: 10.1212/01.WNL.0000149763.15180.00
B-type lamins in health and disease
- Journals
- DOI reference: 10.1016/j.semcdb.2013.12.012
Generation and Characterization of Multipotent Stem Cells from Established Dermal Cultures
- Journals
- DOI reference: 10.1371/journal.pone.0050742
The role of DNA damage in laminopathy progeroid syndromes
- Journals
- DOI reference: 10.1042/BST20110700
Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation
- Journals
- DOI reference: 10.1111/j.1474-9726.2011.00750.x
The accumulation of un-repairable DNA damage in laminopathy progeria fibroblasts is caused by ROS generation and is prevented by treatment with N-acetyl cysteine
- Journals
- DOI reference: 10.1093/hmg/ddr327
A flow cytometry-based screen of nuclear envelope transmembrane proteins identifies NET4/tmem53 as involved in stress-dependent cell cycle withdrawal
- Journals
- DOI reference: 10.1371/journal.pone.0018762
Embryonic and adult isoforms of XLAP2 form microdomains associated with chromatin and the nuclear envelope
- Journals
- DOI reference: 10.1007/s00441-011-1129-2
Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage
- Journals
- DOI reference: 10.1111/acel.12258
